|
Leukemia, Myelocytic, Acute
|
0.500 |
Biomarker
|
disease |
BEFREE |
Regardless of their common cellular distribution, NPM-MLF1 malignancies engender different effects on hematopoiesis compared to NPMc+ counterparts, highlighting possible aberrant nuclear function(s) of NPM in NPMc+ and NPM-MLF1 AML.
|
31675375 |
2019 |
|
leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, different mechanisms would orchestrate the dysregulation of NPM function in NPMc+- versus NPM1-MLF1-associated leukemia.
|
31675375 |
2019 |
|
Childhood Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, different mechanisms would orchestrate the dysregulation of NPM function in NPMc+- versus NPM1-MLF1-associated leukemia.
|
31675375 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Regardless of their common cellular distribution, NPM-MLF1 malignancies engender different effects on hematopoiesis compared to NPMc+ counterparts, highlighting possible aberrant nuclear function(s) of NPM in NPMc+ and NPM-MLF1 AML.
|
31675375 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
|
30224653 |
2018 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Four molecules (LA16c-380H5.2, RP11-203J24.8, MLF1 and SDC4) could potentially serve as diagnostic biomarkers of THCA with high sensitivity and specificity.
|
29340074 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A higher expression ratio of Trib1 to MLF1 was a key determinant for AML development in mouse models, which was also confirmed in human patient samples with acute leukemia.
|
29296815 |
2017 |
|
Leukemogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results indicate that MLF1 is a positive regulator that is critical for C/EBPα stability in the early phases of hematopoiesis and leukemogenesis.
|
29296815 |
2017 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia.
|
29296815 |
2017 |
|
Acute leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A higher expression ratio of Trib1 to MLF1 was a key determinant for AML development in mouse models, which was also confirmed in human patient samples with acute leukemia.
|
29296815 |
2017 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we show that common DNA variants within CPZ at 4p16 and upstream of MLF1 at 3q25 influence neuroblastoma susceptibility and MLF1 likely plays an important role in neuroblastoma tumorigenesis.
|
28545128 |
2017 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, we show that common DNA variants within CPZ at 4p16 and upstream of MLF1 at 3q25 influence neuroblastoma susceptibility and MLF1 likely plays an important role in neuroblastoma tumorigenesis.
|
28545128 |
2017 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we show that common DNA variants within CPZ at 4p16 and upstream of MLF1 at 3q25 influence neuroblastoma susceptibility and MLF1 likely plays an important role in neuroblastoma tumorigenesis.
|
28545128 |
2017 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we show that common DNA variants within CPZ at 4p16 and upstream of MLF1 at 3q25 influence neuroblastoma susceptibility and MLF1 likely plays an important role in neuroblastoma tumorigenesis.
|
28545128 |
2017 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Homozygosity mapping uncovered DPP4, TRHR, and MLF1 as novel candidate susceptibility genes for ASD in the Lebanese.
|
28358038 |
2017 |
|
leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here we report the negative regulation of the HOP complex by human leukemia-associated myeloid leukemia factor 1 (MLF1).
|
28137643 |
2017 |
|
Childhood Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here we report the negative regulation of the HOP complex by human leukemia-associated myeloid leukemia factor 1 (MLF1).
|
28137643 |
2017 |
|
Lymphopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Importantly, Mlf1 deletion reverses B- and T-cell lymphopenia and significantly ameliorates the progressive striatal and cerebellar neurodegeneration observed in Hax1<sup>-/-</sup> mice, with a doubling of the lifespan of Mlf1<sup>-/-</sup>/Hax1<sup>-/-</sup> animals compared to Hax1<sup>-/-</sup> animals.
|
28137643 |
2017 |
|
Cardiomyopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In line with microarray data, MLF1 was profoundly downregulated in in vivo mouse models of cardiomyopathy, and also significantly reduced in the hearts of human patients with dilated cardiomyopathy.
|
28087342 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.500 |
Biomarker
|
disease |
BEFREE |
The development of this sensitive D-FISH strategy for the detection of NPM1/MLF1 fusion adds to the AML FISH testing repertoire and is effective in the detection of this translocation at diagnosis as well as monitoring residual disease in AML patients.
|
25027285 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although t(3;5)(q25.1;q34) or the NPM1/MLF1 rearrangement has been reported mostly as a sole karyotypic abnormality in younger patients, it should also be considered in elderly patients with complex chromosomal abnormalities in acute myeloid leukemia or myelodysplastic syndrome.
|
20471513 |
2010 |
|
MYELODYSPLASTIC SYNDROME
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Although t(3;5)(q25.1;q34) or the NPM1/MLF1 rearrangement has been reported mostly as a sole karyotypic abnormality in younger patients, it should also be considered in elderly patients with complex chromosomal abnormalities in acute myeloid leukemia or myelodysplastic syndrome.
|
20471513 |
2010 |
|
Childhood Myelodysplastic Syndrome
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Although t(3;5)(q25.1;q34) or the NPM1/MLF1 rearrangement has been reported mostly as a sole karyotypic abnormality in younger patients, it should also be considered in elderly patients with complex chromosomal abnormalities in acute myeloid leukemia or myelodysplastic syndrome.
|
20471513 |
2010 |
|
Adult Myelodysplastic Syndrome
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Although t(3;5)(q25.1;q34) or the NPM1/MLF1 rearrangement has been reported mostly as a sole karyotypic abnormality in younger patients, it should also be considered in elderly patients with complex chromosomal abnormalities in acute myeloid leukemia or myelodysplastic syndrome.
|
20471513 |
2010 |
|
Malignant neoplasm of stomach
|
0.310 |
Biomarker
|
disease |
BEFREE |
Six genes (MINT25, RORA, GDNF, ADAM23, PRDM5, MLF1) showed frequent differential methylation between gastric cancer and normal mucosa in the training, test, and validation sets.
|
19375421 |
2009 |